MAN2A1

Across TCGA pan-cancer cohorts, MAN2A1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAN2A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAN2A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAN2A1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, LUAD, and KICH are the cancer types where MAN2A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAN2A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.656	<.001	11	view →
LUAD	Male	II,III,IV	+0.913	<.001	8	view →
KICH	Male	II,III,IV	+1.028	.001	6	view →
THCA	All	All	−0.577	<.001	6	view →
LIHC	All	All	+0.542	<.001	6	view →
BRCA	All	II,III,IV	+0.338	<.001	6	view →
COAD	Female	All	−0.858	<.001	4	view →
CHOL	All	All	+0.923	.022	2	view →
ESCA	All	II,III,IV	+0.739	.039	2	view →
READ	All	All	−0.480	.029	2	view →
PRAD	All	All	+0.264	.042	2	view →
KIRC	All	All	+0.198	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAN2A1–HNSC

Open the HNSC breakdown →