MAN2A1

Across TCGA patient cohorts, MAN2A1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN2A1-associated genes across cancer lineages are 4E-BP1, C-Raf, and mTOR_pS2448. Each is linked with MAN2A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN2A1-to-partner and partner-to-MAN2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MAN2A1-low versus MAN2A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2A1→partner) and Y-score (partner→MAN2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.259	+3.247	<.001	<.001	3	3
UCEC	C-Raf →	+0.118	+1.415	.001	.008	3	3
BLCA	mTOR_pS2448 →	-0.158	-2.321	.034	.035	3	2
LUSC	Acetyl-a-Tubulin-Lys40 →	+0.715	+2.816	.038	.036	3	2
UCEC	ERK2 →	+0.123	+1.440	.016	.020	3	2
UCEC	FoxM1 →	+0.159	+1.237	.020	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1 by MAN2A1 expression — UCEC

Explore this box plot interactively →