MAN2A1

Across TCGA cell cohorts, MAN2A1 mutation is significantly associated with the RNA expression of many other genes, with 2,003 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAN2A1-associated genes across cancer lineages are FAM25A, CYP2A13, and VPS37A. Each is linked with MAN2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN2A1-to-partner and partner-to-MAN2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM25A grouped by MAN2A1-low versus MAN2A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2A1→partner) and Y-score (partner→MAN2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM25A →	+0.112	+4.058	<.001	.007	3	2
CNS	CYP2A13 →	+0.038	+4.459	<.001	<.001	3	2
LARGE_INTESTINE	VPS37A →	+0.686	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	FOXE3 →	+0.076	+1.941	.004	.009	3	2
LARGE_INTESTINE	ADAM7 →	+0.002	+1.860	.001	.005	3	2
KIDNEY	ZNRF4 →	+0.013	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,003 associations by consensus.

FAM25A by MAN2A1 expression — LUNG_SCLC

Explore this box plot interactively →