MAN2A1-DT

Across TCGA pan-cancer cohorts, MAN2A1-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAN2A1-DT data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher MAN2A1-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAN2A1-DT expression acts as an unfavorable survival marker, although some lineages such as READ and ACC show a favorable association.

READ, KIRP, and ACC are the cancer types where MAN2A1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.768	0.395	<.001	50	view →
KIRP	DFS	Median	II,III,IV	0.313	0.694	.001	44	view →
ACC	OS	Median	All	0.906	0.691	.006	35	view →
HNSC	DFS	Tertile	II,III,IV	0.749	0.624	.005	34	view →
BLCA	OS	Tertile	IV	0.194	0.412	.003	32	view →
LUAD	DFS	Median	IV	0.406	0.817	.007	27	view →
CHOL	OS	Median	All	0.794	0.405	.003	26	view →
SKCM	OS	Quartile	All	0.858	0.748	.004	25	view →
PAAD	OS	Tertile	All	0.672	0.426	.004	24	view →
STAD	OS	Tertile	All	0.439	0.692	.009	20	view →
UCS	DFS	Tertile	II,III,IV	0.482	0.136	.011	20	view →
LIHC	OS	Quartile	III,IV	0.625	0.290	.017	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAN2A1-DT–READ (DFS)

Open the READ breakdown →