MAN2A1-DT

Across TCGA pan-cancer cohorts, MAN2A1-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAN2A1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MAN2A1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types MAN2A1-DT is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and UCEC are the cancer types where MAN2A1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAN2A1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−1.099	<.001	10	view →
COAD	Female	All	−0.534	<.001	8	view →
UCEC	All	All	−1.151	<.001	6	view →
BRCA	Female	II,III,IV	−0.325	<.001	6	view →
KICH	All	All	+0.711	.002	5	view →
LUAD	Female	All	−0.332	<.001	5	view →
LIHC	All	II,III,IV	+0.334	.018	3	view →
LUSC	All	All	−0.228	.002	3	view →
HNSC	Male	All	−0.285	.002	2	view →
KIRP	All	All	−0.249	.015	2	view →
HNSC	Female	III,IV	+0.385	.035	1	view →
ESCA	Female	All	−0.253	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAN2A1-DT–BLCA

Open the BLCA breakdown →