MAMSTR

Across TCGA patient cohorts, MAMSTR mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAMSTR-associated genes across cancer lineages are EGFR_pY1068, ERK2, and JNK2. Each is linked with MAMSTR in more than 1 cancer types. Because this analysis shows association rather than direction, both MAMSTR-to-partner and partner-to-MAMSTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MAMSTR-low versus MAMSTR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMSTR→partner) and Y-score (partner→MAMSTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.255	-2.700	.024	.006	3	1
UCEC	ERK2 →	+0.254	+3.459	.003	.005	3	1
UCEC	JNK2 →	+0.186	+3.009	.037	.019	3	1
UCEC	MEK1 →	+0.363	+3.321	.027	.010	3	1
UCEC	MSH2 →	-0.317	-3.295	.002	.009	3	1
UCEC	Notch1 →	+0.149	+2.000	.018	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by MAMSTR expression — UCEC

Explore this box plot interactively →