MAMSTR

Across TCGA pan-cancer cohorts, MAMSTR RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAMSTR data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MAMSTR RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAMSTR expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, BLCA, and HNSC are the cancer types where MAMSTR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.803	0.385	<.001	128	view →
BLCA	DFS	Tertile	All	0.271	0.493	.002	66	view →
HNSC	DFS	Median	All	0.661	0.543	.001	66	view →
LIHC	OS	Median	All	0.426	0.593	<.001	63	view →
KIRP	OS	Quartile	All	0.871	0.968	.012	41	view →
ACC	DFS	Quartile	All	0.292	0.706	.001	29	view →
LUAD	OS	Quartile	II,III,IV	0.550	0.343	.007	26	view →
COAD	DFS	Median	All	0.695	0.854	<.001	23	view →
LUSC	OS	Median	II,III,IV	0.505	0.314	.001	23	view →
KICH	DFS	Quartile	All	0.344	1.000	.002	20	view →
PCPG	DFS	Tertile	All	1.000	0.661	.005	18	view →
UCS	DFS	Quartile	II,III,IV	0.673	0.161	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAMSTR–UVM (DFS)

Open the UVM breakdown →