MAML1

Across TCGA patient cohorts, MAML1 mutation is significantly associated with the RNA expression of many other genes, with 3,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAML1-associated genes across cancer lineages are IL21, MIR4537, and SNORD114-18. Each is linked with MAML1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAML1-to-partner and partner-to-MAML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by MAML1-low versus MAML1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML1→partner) and Y-score (partner→MAML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL21 →	+0.402	+3.819	<.001	.005	3	3
GBM	MIR4537 →	+0.696	+5.352	<.001	.005	3	2
HNSC	SNORD114-18 →	+0.591	+4.912	<.001	.005	3	2
GBM	LNCPRESS2 →	+0.159	+4.969	<.001	.009	3	2
SKCM	MIR4701 →	+0.837	+3.922	.001	<.001	3	2
SKCM	BNIP3P40 →	+0.159	+3.310	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,590 associations by consensus.

IL21 by MAML1 expression — COAD

Explore this box plot interactively →