MAMDC4

Across TCGA patient cohorts, MAMDC4 mutation is significantly associated with the RNA expression of many other genes, with 1,242 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAMDC4-associated genes across cancer lineages are MIR3147, MANEAL, and CKLF. Each is linked with MAMDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAMDC4-to-partner and partner-to-MAMDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3147 grouped by MAMDC4-low versus MAMDC4-high in THYM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMDC4→partner) and Y-score (partner→MAMDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	MIR3147 →	+1.460	+6.845	<.001	<.001	3	2
COAD	MANEAL →	+0.864	+3.321	<.001	.009	3	2
UCEC	CKLF →	+0.577	+2.595	<.001	.005	3	2
UCEC	PINCR →	+0.257	+2.144	<.001	<.001	3	2
UCEC	ZNF232-AS1 →	+0.546	+2.353	.001	.003	3	2
COAD	TSPY26P →	-0.764	-3.687	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,242 associations by consensus.

MIR3147 by MAMDC4 expression — THYM

Explore this box plot interactively →