MAMDC4

Across TCGA cell cohorts, MAMDC4 mutation is significantly associated with the RNA expression of many other genes, with 420 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAMDC4-associated genes across cancer lineages are GSG1L2, ANHX, and LAIR2. Each is linked with MAMDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAMDC4-to-partner and partner-to-MAMDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by MAMDC4-low versus MAMDC4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMDC4→partner) and Y-score (partner→MAMDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GSG1L2 →	+0.299	+4.369	<.001	.008	3	2
SOFT_TISSUE	ANHX →	+0.012	+4.369	<.001	.008	3	2
BONE	LAIR2 →	+0.043	+5.169	<.001	.004	3	1
BONE	LIPK →	+0.023	+5.169	<.001	.004	3	1
BONE	TAS2R41 →	+0.023	+5.169	<.001	.004	3	1
SOFT_TISSUE	OR10H2 →	+0.136	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 420 associations by consensus.

GSG1L2 by MAMDC4 expression — SOFT_TISSUE

Explore this box plot interactively →