Across TCGA patient cohorts, MALRD1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MALRD1-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with MALRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MALRD1-to-partner and partner-to-MALRD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MALRD1→partner) and Y-score (partner→MALRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.328	+3.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.196	-3.169	<.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-3.169	.019	.018	3	1
UCEC	JNK2 →	+0.289	+3.196	.001	.009	3	1
UCEC	P-Cadherin →	-0.142	-3.169	.029	.018	3	1
UCEC	PCNA →	+0.232	+2.700	.017	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

MALRD1 survival (RNA) · tumor vs normal (RNA) · all MALRD1 data types