Across TCGA pan-cancer cohorts, MALRD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MALRD1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MALRD1 RNA is repressed in tumor relative to normal tissue. In most cancer types MALRD1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, KIRP, and LUSC are the cancer types where MALRD1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MALRD1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.