MAL2

Across TCGA patient cohorts, MAL2 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAL2-associated genes across cancer lineages are OR8B6P, DSN1, and DDX19B. Each is linked with MAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAL2-to-partner and partner-to-MAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B6P grouped by MAL2-low versus MAL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAL2→partner) and Y-score (partner→MAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR8B6P →	+0.068	+4.594	<.001	.008	3	2
UCEC	DSN1 →	+0.669	+3.343	.009	.005	3	1
UCEC	DDX19B →	+0.431	+3.407	.003	.004	3	1
UCEC	ABHD3 →	+0.762	+3.332	.006	.005	3	1
UCEC	PKN3 →	+1.007	+3.332	<.001	.005	3	1
UCEC	C1orf50 →	+0.446	+3.364	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

OR8B6P by MAL2 expression — SKCM

Explore this box plot interactively →