MAL2

Across TCGA pan-cancer cohorts, MAL2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MAL2 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MAL2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAL2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, PAAD, and UCEC are the cancer types where MAL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.546	0.907	<.001	148	view →
PAAD	DFS	Quartile	All	0.172	0.535	<.001	51	view →
UCEC	DFS	Tertile	All	0.497	0.769	<.001	40	view →
SKCM	OS	Tertile	All	0.696	0.833	<.001	37	view →
HNSC	OS	Quartile	All	0.833	0.694	.001	27	view →
BRCA	OS	Median	All	0.492	0.688	<.001	25	view →
KIRC	DFS	Quartile	All	0.807	0.527	<.001	23	view →
LGG	DFS	Quartile	All	0.527	0.335	.002	17	view →
ESCA	OS	Median	All	0.440	1.000	.008	16	view →
LIHC	OS	Median	II,III,IV	0.475	0.735	.001	16	view →
KICH	DFS	Quartile	II,III,IV	0.374	0.913	.006	13	view →
ACC	OS	Median	IV	0.798	0.288	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MAL2–UVM (DFS)

Open the UVM breakdown →