MAL2

Across TCGA patient cohorts, MAL2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAL2-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and EGFR_pY1068. Each is linked with MAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAL2-to-partner and partner-to-MAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAL2-low versus MAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAL2→partner) and Y-score (partner→MAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.193	+3.019	<.001	.019	3	1
UCEC	C-Raf →	+0.325	+3.000	<.001	.037	3	1
UCEC	EGFR_pY1068 →	-0.394	-3.000	.006	.037	2	1
UCEC	ATM →	-0.627	-3.000	.016	.037	2	1
UCEC	mTOR_pS2448 →	-0.212	-3.000	.013	.037	1	1
UCEC	c-Met_pY1235 →	+0.089	+3.000	.037	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-7-cleavedD198 by MAL2 expression — UCEC

Explore this box plot interactively →