MAL2

Across TCGA cell cohorts, MAL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,302 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAL2-associated GO terms across cancer lineages are Positive regulation of iron ion transport, Positive regulation of iron ion transmembrane transport, and Cytotoxic T cell degranulation. Each is linked with MAL2 in more than 10 cancer types. Because this analysis shows association rather than direction, both MAL2-to-partner and partner-to-MAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of iron ion transport grouped by MAL2-low versus MAL2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAL2→partner) and Y-score (partner→MAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of iron ion transport →	+1.626	+4.332	.001	.001	3	11
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.626	+4.332	.001	.001	3	11
STOMACH	Cytotoxic T cell degranulation →	+0.313	+4.302	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Lipoxygenase pathway →	-0.263	-4.490	.006	.001	3	10
LIVER	Positive regulation of endothelial cell development →	+0.377	+3.491	<.001	<.001	3	10
LIVER	Positive regulation of establishment of endothelial barrier →	+0.377	+3.491	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,302 associations by consensus.

Positive regulation of iron ion transport by MAL2 expression — URINARY_TRACT

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