Across TCGA patient cohorts, MAK16 protein abundance is significantly associated with the RNA expression of many other genes, with 15,049 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAK16-associated genes across cancer lineages are BEST1, RASGRP4, and CXCR2. Each is linked with MAK16 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAK16-to-partner and partner-to-MAK16 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAK16→partner) and Y-score (partner→MAK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BEST1 →	-0.595	-0.305	<.001	<.001	3	7
HNSC	RASGRP4 →	-0.461	-0.221	<.001	.001	3	7
LSCC	CXCR2 →	-0.822	-0.284	<.001	<.001	3	6
LSCC	PELATON →	-0.592	-0.306	<.001	<.001	3	6
OV	GAS5 →	+0.875	+0.395	<.001	.002	3	6
GBM	IRAG1 →	-0.836	-0.314	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,049 associations by consensus.

Exploration

MAK16 survival (RNA) · tumor vs normal (RNA) · all MAK16 data types