MAK

Across TCGA patient cohorts, MAK mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAK-associated genes across cancer lineages are Rad50, Annexin-1, and Caspase-7-cleavedD198. Each is linked with MAK in more than 1 cancer types. Because this analysis shows association rather than direction, both MAK-to-partner and partner-to-MAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by MAK-low versus MAK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAK→partner) and Y-score (partner→MAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.315	-2.736	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.466	+3.169	.016	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.443	+2.321	.042	.033	3	2
UCEC	4E-BP1 →	+0.292	+2.000	.003	.029	3	2
UCEC	FASN →	+0.337	+1.502	.020	.030	3	1
UCEC	FoxM1 →	+0.207	+2.247	.029	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Rad50 by MAK expression — UCEC

Explore this box plot interactively →