MAK

Across TCGA cell cohorts, MAK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAK-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Cell cycle G1/S phase transition, and Regulation of protein localization to Cajal body. Each is linked with MAK in more than 12 cancer types. Because this analysis shows association rather than direction, both MAK-to-partner and partner-to-MAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by MAK-low versus MAK-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAK→partner) and Y-score (partner→MAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of RNA export from nucleus →	+0.111	+0.167	<.001	.001	3	13
BONE	Cell cycle G1/S phase transition →	+0.075	+0.145	.002	.002	3	9
BREAST	Regulation of protein localization to Cajal body →	+0.069	+0.230	.005	.007	3	9
BREAST	Positive regulation of protein localization to Cajal body →	+0.069	+0.230	.005	.007	3	9
BREAST	Negative regulation of myoblast fusion →	+0.117	+0.321	<.001	<.001	3	9
BREAST	Regulation of transcription initiation by RNA polymerase II →	+0.068	+0.255	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,233 associations by consensus.

Negative regulation of RNA export from nucleus by MAK expression — SOFT_TISSUE

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