Across TCGA patient cohorts, MAGI2 mutation is significantly associated with the RNA expression of many other genes, with 4,601 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGI2-associated genes across cancer lineages are POLR1F, PSMB7, and POC1A. Each is linked with MAGI2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAGI2-to-partner and partner-to-MAGI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI2→partner) and Y-score (partner→MAGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLR1F →	+0.378	+1.534	<.001	<.001	3	5
UCEC	PSMB7 →	+0.283	+2.621	<.001	<.001	3	5
STAD	POC1A →	+0.666	+2.712	<.001	.003	3	4
STAD	SKA3 →	+0.679	+3.338	.002	.004	3	4
UCEC	NDRG2 →	-0.772	-1.877	<.001	<.001	3	4
UCEC	ESCO2 →	+0.472	+1.844	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,601 associations by consensus.

Exploration

MAGI2 survival (RNA) · tumor vs normal (RNA) · all MAGI2 data types