MAGI2-AS3

Across TCGA pan-cancer cohorts, MAGI2-AS3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MAGI2-AS3 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MAGI2-AS3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGI2-AS3 expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

UVM, LUSC, and BLCA are the cancer types where MAGI2-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.253	0.860	.002	53	view →
LUSC	OS	Median	All	0.314	0.489	<.001	44	view →
BLCA	OS	Median	All	0.544	0.666	.002	41	view →
UCS	DFS	Median	II,III,IV	0.623	0.252	.001	36	view →
LGG	OS	Median	All	0.755	0.865	<.001	28	view →
ACC	DFS	Tertile	III,IV	0.449	0.074	.001	26	view →
SKCM	OS	Median	All	0.387	0.286	.006	23	view →
PCPG	DFS	Quartile	All	0.951	0.753	.006	23	view →
HNSC	DFS	Tertile	III,IV	0.359	0.259	.011	21	view →
KIRC	DFS	Quartile	All	0.878	0.708	.007	20	view →
KIRP	DFS	Median	II,III,IV	0.806	0.277	.017	16	view →
STAD	OS	Tertile	All	0.502	0.652	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MAGI2-AS3–UVM (DFS)

Open the UVM breakdown →