MAGI2-AS3

Across TCGA pan-cancer cohorts, MAGI2-AS3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MAGI2-AS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAGI2-AS3 RNA is repressed in tumor relative to normal tissue. In most cancer types MAGI2-AS3 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and LUAD are the cancer types where MAGI2-AS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGI2-AS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.766	<.001	12	view →
BLCA	Male	IV	−2.237	<.001	11	view →
LUAD	Female	III,IV	−1.555	<.001	11	view →
KIRP	All	II,III,IV	−1.158	<.001	9	view →
COAD	Female	II,III,IV	−0.636	<.001	9	view →
LUSC	Female	II,III,IV	−2.008	<.001	8	view →
UCEC	All	III,IV	−2.854	<.001	6	view →
BRCA	All	III,IV	−1.695	<.001	6	view →
KICH	Female	All	−1.431	<.001	6	view →
THCA	Male	All	−0.744	<.001	6	view →
LIHC	Female	II,III,IV	−1.319	<.001	5	view →
CHOL	All	All	−0.944	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MAGI2-AS3–KIRC

Open the KIRC breakdown →