MAGI1

Across TCGA pan-cancer cohorts, MAGI1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MAGI1 data layer compared with 28 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MAGI1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MAGI1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and UCEC are the cancer types where MAGI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.758	0.269	.002	30	view →
GBM	OS	Median	All	0.948	0.771	.002	18	view →
UCEC	DFS	Tertile	All	0.968	0.737	.003	12	view →
LSCC	OS	Median	All	0.953	0.820	.009	8	view →
LUAD	DFS	Tertile	II,III,IV	0.668	0.918	.018	7	view →
PDAC	DFS	Tertile	All	0.529	0.336	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MAGI1–CCRCC (DFS)

Open the CCRCC breakdown →