MAGI1-AS1

Across TCGA pan-cancer cohorts, MAGI1-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MAGI1-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MAGI1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAGI1-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, UVM, and HNSC are the cancer types where MAGI1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.905	0.741	<.001	98	view →
UVM	OS	Tertile	All	0.136	0.919	<.001	45	view →
HNSC	DFS	Tertile	All	0.718	0.584	.015	45	view →
READ	OS	Tertile	III,IV	0.296	0.826	<.001	45	view →
UCEC	DFS	Tertile	IV	0.278	0.740	.001	36	view →
KIRP	DFS	Tertile	II,III,IV	0.945	0.613	.009	30	view →
ESCA	DFS	Tertile	All	0.306	0.880	.007	24	view →
SKCM	OS	Tertile	III,IV	0.264	0.710	<.001	18	view →
TGCT	OS	Tertile	III,IV	0.501	1.000	.014	18	view →
MESO	OS	Tertile	III,IV	0.036	0.563	<.001	18	view →
CESC	DFS	Tertile	III,IV	1.000	0.569	.040	12	view →
GBM	DFS	Tertile	All	0.103	0.295	.040	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MAGI1-AS1–BRCA (DFS)

Open the BRCA breakdown →