MAGED4

Across TCGA pan-cancer cohorts, MAGED4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAGED4 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher MAGED4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGED4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BLCA show a favorable association.

KICH, STAD, and LUSC are the cancer types where MAGED4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
STAD	OS	Tertile	All	0.318	0.493	.009	51	view →
LUSC	OS	Tertile	II,III,IV	0.691	0.478	.002	45	view →
LGG	DFS	Median	All	0.672	0.800	<.001	42	view →
ACC	DFS	Tertile	All	0.112	0.515	.004	42	view →
BLCA	OS	Tertile	III,IV	0.659	0.504	.012	40	view →
KIRP	OS	Median	All	0.515	0.912	<.001	39	view →
SARC	DFS	Quartile	All	0.307	0.588	<.001	31	view →
KIRC	DFS	Tertile	III,IV	0.583	0.764	.011	30	view →
LIHC	OS	Tertile	All	0.535	0.707	.008	27	view →
PAAD	DFS	Tertile	All	0.478	0.295	.003	24	view →
UCS	DFS	Median	II,III,IV	0.499	0.204	.016	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAGED4–KICH (DFS)

Open the KICH breakdown →