MAGED4

Across TCGA pan-cancer cohorts, MAGED4 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MAGED4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MAGED4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAGED4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, HNSC, and LUSC are the cancer types where MAGED4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGED4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.008	<.001	8	view →
HNSC	All	II,III,IV	+0.006	.004	7	view →
LUSC	All	All	+0.016	<.001	5	view →
LIHC	Female	III,IV	+0.010	.013	4	view →
LUAD	All	All	+0.010	.001	2	view →
THCA	All	All	−0.005	.015	2	view →
ESCA	Male	All	+0.054	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MAGED4–KIRP

Open the KIRP breakdown →