MAGEB4

Across TCGA patient cohorts, MAGEB4 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEB4-associated genes across cancer lineages are ASNS, 4E-BP1, and 14-3-3_beta. Each is linked with MAGEB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEB4-to-partner and partner-to-MAGEB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MAGEB4-low versus MAGEB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB4→partner) and Y-score (partner→MAGEB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.427	+2.415	<.001	.002	3	2
UCEC	4E-BP1 →	+0.419	+1.893	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.089	-2.060	.004	.004	3	1
UCEC	eIF4E →	+0.191	+1.893	.003	<.001	3	1
UCEC	eIF4G →	+0.260	+2.502	.007	.001	3	1
UCEC	A-Raf_pS299 →	-0.156	-4.087	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by MAGEB4 expression — UCEC

Explore this box plot interactively →