MAGEB18

Across TCGA cell cohorts, MAGEB18 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEB18-associated genes across cancer lineages are SPRR4, OR2F1, and ASB15. Each is linked with MAGEB18 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEB18-to-partner and partner-to-MAGEB18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR4 grouped by MAGEB18-low versus MAGEB18-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB18→partner) and Y-score (partner→MAGEB18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPRR4 →	+0.038	+4.887	<.001	.009	3	1
SKIN	OR2F1 →	+0.006	+4.684	<.001	.002	3	1
LARGE_INTESTINE	ASB15 →	+0.016	+3.453	<.001	.009	3	1
LARGE_INTESTINE	ITGAD →	+0.011	+3.510	<.001	.003	3	1
LARGE_INTESTINE	ACSM6 →	+0.025	+3.584	<.001	.002	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SPRR4 by MAGEB18 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →