MAGEB10

Across TCGA pan-cancer cohorts, MAGEB10 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MAGEB10 data layer compared with 15 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MAGEB10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEB10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, HNSC, and ESCA are the cancer types where MAGEB10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	OS	Median	IV	0.156	0.708	.007	12	view →
ESCA	OS	Median	II,III,IV	0.206	0.686	.004	12	view →
COAD	DFS	Median	III,IV	0.035	0.698	<.001	12	view →
LIHC	OS	Median	All	0.025	0.777	<.001	12	view →
UCEC	DFS	Median	All	0.964	0.630	.016	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	0.297	0.729	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MAGEB10–THYM (OS)

Open the THYM breakdown →