MAGEA8

Across TCGA patient cohorts, MAGEA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,831 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MAGEA8-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, DNA biosynthetic process, and Positive regulation of chromosome organization. Each is linked with MAGEA8 in more than 24 cancer types. Because this analysis shows association rather than direction, both MAGEA8-to-partner and partner-to-MAGEA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by MAGEA8-low versus MAGEA8-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA8→partner) and Y-score (partner→MAGEA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Regulation of DNA-templated transcription initiation →	+0.068	+0.085	<.001	<.001	3	25
DLBC	DNA biosynthetic process →	+0.062	+0.091	<.001	<.001	3	25
STAD	Positive regulation of chromosome organization →	+0.089	+0.421	<.001	.001	3	24
DLBC	Positive regulation of DNA-templated transcription initiation →	+0.086	+0.122	<.001	<.001	3	24
STAD	RNA polymerase II preinitiation complex assembly →	+0.075	+0.546	<.001	<.001	3	24
DLBC	Protein-DNA complex assembly →	+0.046	+0.079	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,831 associations by consensus.

Regulation of DNA-templated transcription initiation by MAGEA8 expression — DLBC

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