MAGEA8

Across TCGA patient cohorts, MAGEA8 protein abundance is significantly associated with the RNA expression of many other genes, with 257 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAGEA8-associated genes across cancer lineages are NDRG3, INTS9, and NFKBIB. Each is linked with MAGEA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA8-to-partner and partner-to-MAGEA8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAGEA8 versus NDRG3 in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA8→partner) and Y-score (partner→MAGEA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NDRG3 →	+0.562	+0.846	.002	.001	3	1
LSCC	INTS9 →	+0.831	+0.958	.003	.002	3	1
LSCC	NFKBIB →	+0.571	+0.926	.001	.004	3	1
LSCC	DLX5 →	+2.442	+0.864	.001	.007	3	1
LSCC	KCNQ4 →	+0.718	+0.863	.001	.002	3	1
LSCC	CCND2 →	+1.800	+1.141	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 257 associations by consensus.

MAGEA8 vs NDRG3 — LSCC

Explore this scatter interactively →