MAGEA8

Across TCGA patient cohorts, MAGEA8 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEA8-associated genes across cancer lineages are A-Raf_pS299, TIGAR, and eEF2. Each is linked with MAGEA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA8-to-partner and partner-to-MAGEA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MAGEA8-low versus MAGEA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA8→partner) and Y-score (partner→MAGEA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.156	-3.000	<.001	<.001	3	2
UCEC	TIGAR →	+0.124	+3.000	.027	<.001	3	2
UCEC	eEF2 →	+0.324	+3.169	.013	.018	3	1
UCEC	EGFR_pY1068 →	-0.287	-2.247	.001	.001	3	1
UCEC	ERK2 →	+0.161	+1.847	.022	.008	3	1
UCEC	JNK2 →	+0.203	+2.247	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

A-Raf_pS299 by MAGEA8 expression — UCEC

Explore this box plot interactively →