MAGEA8-AS1

Across TCGA pan-cancer cohorts, MAGEA8-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MAGEA8-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MAGEA8-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MAGEA8-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where MAGEA8-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGEA8-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.154	<.001	6	view →
KICH	Male	II,III,IV	−0.146	.009	4	view →
LUSC	All	All	+0.207	.004	2	view →
HNSC	Male	II,III,IV	+0.102	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MAGEA8-AS1–THCA

Open the THCA breakdown →