Across TCGA pan-cancer cohorts, MAGEA7P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MAGEA7P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MAGEA7P RNA is repressed in tumor relative to normal tissue. In most cancer types MAGEA7P is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and HNSC are the cancer types where MAGEA7P tumor–normal differential expression is most reproducible.