MAGEA4-AS1

Across TCGA pan-cancer cohorts, MAGEA4-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MAGEA4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAGEA4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAGEA4-AS1 is over-expressed in tumor.

HNSC, LUSC, and BLCA are the cancer types where MAGEA4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGEA4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.756	<.001	10	view →
LUSC	Male	All	+1.475	<.001	5	view →
BLCA	All	All	+0.723	.019	4	view →
BRCA	Female	All	+0.167	.009	4	view →
ESCA	All	II,III,IV	+0.140	.019	3	view →
STAD	All	All	+0.413	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MAGEA4-AS1–HNSC

Open the HNSC breakdown →