MAGEA2B

Across TCGA cell cohorts, MAGEA2B mutation is significantly associated with the mutation status of many other genes, with 73 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAGEA2B-associated genes across cancer lineages are SALL4, CDH4, and GRIA3. Each is linked with MAGEA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA2B-to-partner and partner-to-MAGEA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SALL4 grouped by MAGEA2B-low versus MAGEA2B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA2B→partner) and Y-score (partner→MAGEA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SALL4 →	+4.063	+3.584	.003	.003	1	2
LUNG_NSCLC_LUAD	CDH4 →	+2.670	+3.165	.004	.004	1	2
LUNG_SCLC	GRIA3 →	+3.777	+3.307	.005	.005	1	2
LUNG_NSCLC_LUAD	MAGEA2 →	+4.478	+4.133	<.001	<.001	1	2
LUNG_SCLC	HYDIN →	+2.192	+3.222	.003	.003	1	2
LUNG_NSCLC_LUAD	AMBRA1 →	+5.063	+3.924	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

SALL4 by MAGEA2B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →