MAGEA2

Across TCGA cell cohorts, MAGEA2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAGEA2-associated genes across cancer lineages are OR11H12, OR2A14, and OR4S1. Each is linked with MAGEA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA2-to-partner and partner-to-MAGEA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H12 grouped by MAGEA2-low versus MAGEA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA2→partner) and Y-score (partner→MAGEA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR11H12 →	+0.082	+3.196	<.001	.007	3	2
BLOOD_Myeloma	OR2A14 →	+0.033	+4.807	<.001	.006	3	1
BREAST	OR4S1 →	+0.023	+5.781	<.001	.001	3	1
BREAST	TGIF2LY →	+0.022	+5.169	<.001	.005	3	1
LUNG_SCLC	TDO2 →	+1.229	+3.343	<.001	.005	3	1
LUNG_SCLC	RDH8 →	+0.058	+2.616	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR11H12 by MAGEA2 expression — SKIN

Explore this box plot interactively →