MAGEA2

Across TCGA pan-cancer cohorts, MAGEA2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MAGEA2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAGEA2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEA2 expression acts as an unfavorable survival marker, although some lineages such as LAML and SKCM show a favorable association.

KIRC, KICH, and COAD are the cancer types where MAGEA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.176	0.662	<.001	144	view →
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
COAD	OS	Tertile	All	0.512	0.818	.001	75	view →
LIHC	DFS	Tertile	All	0.415	0.583	.004	69	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
DLBC	OS	Tertile	All	0.526	0.933	.024	36	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
LAML	DFS	Tertile	All	0.658	0.300	.005	36	view →
READ	DFS	Tertile	IV	0.112	0.811	.008	36	view →
ACC	DFS	Tertile	All	0.068	0.667	.005	36	view →
SKCM	DFS	Tertile	All	0.273	0.159	.013	16	view →
BLCA	DFS	Tertile	III,IV	0.451	0.256	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MAGEA2–KIRC (OS)

Open the KIRC breakdown →