MAGEA2

Across TCGA cell cohorts, MAGEA2 mutation is significantly associated with the mutation status of many other genes, with 115 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAGEA2-associated genes across cancer lineages are MAGEA1, COL1A2, and OR5J2. Each is linked with MAGEA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAGEA2-to-partner and partner-to-MAGEA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEA1 grouped by MAGEA2-low versus MAGEA2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA2→partner) and Y-score (partner→MAGEA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAGEA1 →	+4.297	+4.857	.009	.009	1	4
LUNG_SCLC	COL1A2 →	+2.784	+2.655	.007	.007	1	2
LUNG_SCLC	OR5J2 →	+4.369	+3.066	.005	.005	1	2
LUNG_SCLC	PACS2 →	+4.369	+3.066	.005	.005	1	2
LUNG_SCLC	MAGEA2B →	+5.369	+4.192	<.001	<.001	1	2
LUNG_SCLC	CNTF →	+4.369	+3.066	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

MAGEA1 by MAGEA2 expression — BREAST

Explore this box plot interactively →