Across TCGA patient cohorts, MAGEA12 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEA12-associated genes across cancer lineages are Cyclin-B1, Fibronectin, and ACVRL1. Each is linked with MAGEA12 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGEA12-to-partner and partner-to-MAGEA12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA12→partner) and Y-score (partner→MAGEA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.849	+4.169	<.001	<.001	3	3
LUAD	Fibronectin →	+0.503	+3.459	.037	.005	3	2
LUAD	ACVRL1 →	-0.149	-3.169	.027	.018	3	2
LUAD	mTOR_pS2448 →	-0.184	-2.321	.043	.035	3	2
LUAD	Akt_pT308 →	-0.242	-2.321	.019	.033	3	2
UCEC	14-3-3_beta →	-0.082	-2.060	.013	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

MAGEA12 survival (RNA) · tumor vs normal (RNA) · all MAGEA12 data types