Across TCGA pan-cancer cohorts, MAGEA12 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAGEA12 data layer compared with 9 for mutation status.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MAGEA12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEA12 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BLCA show a favorable association.
KIRP, COAD, and PAAD are the cancer types where MAGEA12 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.