Across TCGA cell cohorts, MAGEA12 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAGEA12-associated genes across cancer lineages are FCRL4, TRIM64, and DGKK. Each is linked with MAGEA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA12-to-partner and partner-to-MAGEA12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA12→partner) and Y-score (partner→MAGEA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FCRL4 →	+0.009	+3.930	<.001	.003	3	1
SKIN	TRIM64 →	+0.020	+4.437	<.001	.004	3	1
SKIN	DGKK →	+0.239	+4.139	<.001	.007	3	1
LARGE_INTESTINE	TMCO5A →	+0.026	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	IL5 →	+0.222	+3.464	<.001	.004	3	1
LUNG_NSCLC_LUAD	CYP4A22 →	+0.035	+4.523	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

MAGEA12 survival (RNA) · tumor vs normal (RNA) · all MAGEA12 data types