MAGEA10

Across TCGA pan-cancer cohorts, MAGEA10 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MAGEA10 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher MAGEA10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEA10 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CESC, READ, and ACC are the cancer types where MAGEA10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.095	0.755	<.001	18	view →
READ	OS	Median	II,III,IV	0.187	0.644	.023	12	view →
ACC	OS	Median	All	0.268	0.802	.010	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	IV	0.753	0.283	.041	4	view →
LUSC	OS	Median	All	0.158	0.410	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MAGEA10–CESC (OS)

Open the CESC breakdown →