MAGEA10

Across TCGA pan-cancer cohorts, MAGEA10 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MAGEA10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAGEA10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAGEA10 is over-expressed in tumor, although a few such as PRAD and KICH show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where MAGEA10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGEA10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.663	.004	5	view →
BRCA	Female	All	+0.189	.019	4	view →
KIRC	Male	All	+0.031	.001	3	view →
LUSC	Male	All	+1.574	<.001	2	view →
LUAD	All	All	+0.374	.019	2	view →
READ	All	All	+0.061	.025	2	view →
KIRP	All	IV	+0.022	.024	2	view →
PRAD	All	All	−0.009	.026	2	view →
KICH	All	II,III,IV	−0.011	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MAGEA10–HNSC

Open the HNSC breakdown →