Across TCGA pan-cancer cohorts, MAGEA1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MAGEA1 data layer compared with 9 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MAGEA1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEA1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.
KIRP, COAD, and THCA are the cancer types where MAGEA1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.