Across TCGA pan-cancer cohorts, MAGEA1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MAGEA1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAGEA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAGEA1 is over-expressed in tumor.
HNSC, LIHC, and BLCA are the cancer types where MAGEA1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGEA1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.