MAG

Across TCGA patient cohorts, MAG mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAG-associated genes across cancer lineages are Cyclin-E2, Chk2, and Di-Ras3. Each is linked with MAG in more than 2 cancer types. Because this analysis shows association rather than direction, both MAG-to-partner and partner-to-MAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MAG-low versus MAG-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAG→partner) and Y-score (partner→MAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.176	+2.828	.008	.033	3	3
UCEC	Chk2 →	-0.236	-3.169	.021	.019	3	2
UCEC	Di-Ras3 →	-0.153	-2.115	.018	.019	3	2
COAD	XBP1 →	+0.245	+3.182	.004	.009	3	2
STAD	alpha-Catenin →	+0.258	+3.169	.048	.019	3	1
STAD	Tuberin_pT1462 →	-0.242	-3.169	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Cyclin-E2 by MAG expression — STAD

Explore this box plot interactively →