MAG

Across TCGA pan-cancer cohorts, MAG RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MAG data layer compared with 10 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MAG RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAG expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

UVM, BRCA, and KIRP are the cancer types where MAG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.610	0.231	.004	58	view →
BRCA	DFS	Median	III,IV	0.878	0.708	<.001	55	view →
KIRP	DFS	Tertile	IV	0.039	1.000	.006	36	view →
READ	OS	Quartile	II,III,IV	0.433	0.771	.002	35	view →
UCS	DFS	Median	II,III,IV	0.500	0.137	.004	30	view →
THCA	DFS	Quartile	II,III,IV	0.710	0.936	.007	26	view →
THYM	DFS	Tertile	II,III,IV	0.779	0.950	.008	19	view →
UCEC	DFS	Median	IV	0.670	0.276	.010	18	view →
LIHC	OS	Median	II,III,IV	0.586	0.794	.004	16	view →
SKCM	DFS	Median	III,IV	0.594	0.386	.005	13	view →
LUAD	OS	Median	All	0.739	0.602	.020	8	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MAG–UVM (DFS)

Open the UVM breakdown →