MAG

Across TCGA cell cohorts, MAG mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAG-associated genes across cancer lineages are SIGLECL1, POTEH, and MT1A. Each is linked with MAG in more than 1 cancer types. Because this analysis shows association rather than direction, both MAG-to-partner and partner-to-MAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLECL1 grouped by MAG-low versus MAG-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAG→partner) and Y-score (partner→MAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLECL1 →	+0.018	+4.266	<.001	.004	3	2
LUNG_NSCLC_LUAD	POTEH →	+0.806	+4.009	<.001	.002	3	2
LARGE_INTESTINE	MT1A →	+2.634	+3.364	<.001	.002	3	2
SKIN	OR13H1 →	+0.080	+4.977	<.001	.007	3	2
LUNG_SCLC	PRAMEF12 →	+0.132	+4.684	<.001	<.001	3	1
LUNG_SCLC	OR6F1 →	+0.068	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

SIGLECL1 by MAG expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →