MAFG-DT

Across TCGA pan-cancer cohorts, MAFG-DT RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MAFG-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAFG-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAFG-DT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where MAFG-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAFG-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+2.739	<.001	12	view →
BLCA	All	All	+1.550	<.001	11	view →
LUAD	Female	III,IV	+1.334	<.001	11	view →
KIRC	Female	III,IV	−0.813	<.001	10	view →
LIHC	Male	II,III,IV	+2.238	<.001	9	view →
KICH	Female	II,III,IV	−1.622	<.001	8	view →
LUSC	Male	II,III,IV	+1.382	<.001	8	view →
KIRP	Male	II,III,IV	+1.170	<.001	8	view →
READ	All	All	+1.872	<.001	7	view →
STAD	All	II,III,IV	+1.141	<.001	7	view →
BRCA	All	III,IV	+1.208	<.001	6	view →
CHOL	Male	All	+3.051	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MAFG-DT–COAD

Open the COAD breakdown →